A Comprehensive Network Pharmacology Study on the Diabetes-Fighting Capabilities of Yacon Leaf Extract

Authors

  • Arsianita Ester Wawo Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia
  • Herny Emma Inonta Simbala Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia
  • Fatimawali Fatimawali Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia
  • Trina Ekawati Tallei Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia; Department of Biology, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia

DOI:

https://doi.org/10.60084/mp.v2i2.161

Keywords:

Smallanthus sonchifolius, Diabetes Mellitus Type 2, Protein target, Network pharmacology

Abstract

Indonesia ranks fourth in the world for the number of diabetes mellitus (DM) sufferers. DM is a group of metabolic disorders characterized by hyperglycemia due to insulin abnormalities. This research employs Network Pharmacology analysis to examine the target proteins and pharmacological network profiles predicted to be influenced by compounds in the leaves of Smallanthus sonchifolius (yacon) for their anti-diabetic effects. Gas chromatography-mass spectrometry (GC-MS) identified 41 secondary metabolite compounds in yacon leaves, seven of which have a Pa value > 0.5. Compound C28 has the highest Pa value as an insulin promoter, at 0.662. A total of 129 target proteins were found for the secondary metabolite compounds in yacon leaves, and 5,112 target proteins were identified for Type 2 Diabetes Mellitus (T2DM). The intersection analysis between yacon leaves and T2DM revealed 32 common proteins. Network analysis highlighted 10 top proteins: ESR1, PPAR-α, HMGCR, CYP19A1, PPARD, PTP1N, GRIN2B, FYN, AR, and SHBG. Among these, PPAR-α shows great potential and promising prospects as a target for further exploration. Considering several parameters, it can be concluded that PPAR-α is a promising protein and a potential target for new drug candidates for T2DM.

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Published

2024-06-19

How to Cite

Wawo, A. E., Simbala, H. E. I., Fatimawali, F., & Tallei, T. E. (2024). A Comprehensive Network Pharmacology Study on the Diabetes-Fighting Capabilities of Yacon Leaf Extract. Malacca Pharmaceutics, 2(2), 41–51. https://doi.org/10.60084/mp.v2i2.161

Issue

Vol. 2 No. 2 (2024): September 2024

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Article

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Copyright (c) 2024 Arsianita Ester Wawo, Herny Emma Inonta Simbala, Fatimawali Fatimawali, Trina Ekawati Tallei

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