Therapeutic Potential of Aceh's Syzygium polyanthum in Reducing Uric Acid in Rattus Norvegicus

Authors

  • Nasrullah Nasrullah School of Medicine, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
  • Masra Lena Siregar Department of Internal Medicine, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
  • Suryawati Suryawati Department of Pharmacology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia

DOI:

https://doi.org/10.60084/mp.v2i2.210

Keywords:

Flavonoids, Phenolic acid, Alkaloid, Gout, Xanthine oxidase

Abstract

This research aims to evaluate the anti-hyperuricemic activity of Syzygium polyanthum ethanolic extract in hyperuricemic male rats (Rattus norvegicus) induced by liver juice.  A total of 25 animals were divided into five groups: a negative control group, a positive control group, and three treatment groups receiving S. polyanthum extract at doses of 150, 200, and 250 mg/kg body weight, respectively. The result showed that the dose of 250 mg/kg body weight resulted in the highest decrease of uric acid plasma, measuring 3.44 ± 2.03 mg/dL. This reduction is comparable to the effect of allopurinol, which showed a decrease of 3.70 ± 1.54 mg/dL. A minimum dose-dependent activity was observed. To conclude, the administration of ethanolic extract of S. polyanthum for 14 days significantly reduced uric acid levels. Further exploration of higher doses or a long-term treatment period to enhance its effectiveness is needed.

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Published

2024-09-06

How to Cite

Nasrullah, N., Siregar, M. L., & Suryawati, S. (2024). Therapeutic Potential of Aceh’s Syzygium polyanthum in Reducing Uric Acid in Rattus Norvegicus . Malacca Pharmaceutics, 2(2), 63–67. https://doi.org/10.60084/mp.v2i2.210

Issue

Vol. 2 No. 2 (2024): September 2024

Section

Article

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Copyright (c) 2024 Nasrullah Nasrullah, Masra Lena Siregar, Suryawati Suryawati

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