In Vitro Antioxidant Activity of Chrysanthemum indicum Flowers Extract and Its Fraction

Authors

  • Jeclin Inebel Dolongtelide Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia
  • Fatimawali Fatimawali Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia; Department of Chemistry, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia
  • Trina Ekawati Tallei Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia
  • Elly Juliana Suoth Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia
  • Herny Emma Inonta Simbala Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia
  • Irma Antasionasti Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia
  • Marko Jeremia Kalalo Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia

DOI:

https://doi.org/10.60084/mp.v1i2.26

Keywords:

Chrysantemum indicum, Antioxidant, in vitro, DPPH

Abstract

Chrysanthemum indicum L., commonly known as Chrysanthemum flower, is an herbaceous plant that has a long-established history of medicinal usage. There has been extensive research about C. indicium L, especially about its antioxidant activities, but not much has been done on its fraction. This study aimed to explore the efficacy of the ethanol extract and its fraction derived from Chrysanthemum flowers in scavenging free radicals. The antioxidant potential of the ethanol extract, as well as its aqueous and n-hexane fractions, was evaluated using the 2,2-diphenyl-1-picrilhidrazine (DPPH) method in vitro. The degree of antioxidant activity was quantified by determining the IC50 value, which corresponds to the concentration of the extract or fractions required to inhibit 50% of DPPH free radicals. The results obtained from this investigation provide strong evidence that the ethanolic extract, as well as its aqueous and n-hexane fractions, exhibited significant antioxidant activity. The measured IC50 values for the ethanolic extract, aqueous fraction, and n-hexane fraction were 1.350 µg/mL, 1.109 µg/mL, and 7.588 µg/mL, respectively.

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Published

2023-07-19

How to Cite

Dolongtelide, J. I., Fatimawali, F., Tallei, T. E., Suoth, E. J., Simbala, H. E. I., Antasionasti, I., & Kalalo, M. J. (2023). In Vitro Antioxidant Activity of Chrysanthemum indicum Flowers Extract and Its Fraction. Malacca Pharmaceutics, 1(2), 43–47. https://doi.org/10.60084/mp.v1i2.26

Issue

Vol. 1 No. 2 (2023): October 2023

Section

Article

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Copyright (c) 2023 Jeclin Inebel Dolongtelide, Fatimawali Fatimawali, Trina Ekawati Tallei, Elly Juliana Suoth, Herny Emma Inonta Simbala, Irma Antasionasti, Marko Jeremia Kalalo

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.