Antibacterial Potential of Geothermal Plant Extracts from Jaboi Crater, Indonesia: A Thin Layer Chromatography-Bioautography Approach

Khairan Khairan; Farhil Mubaraq; Nur Balqis Maulydia; Khalijah Awang; Rinaldi Idroes

doi:10.60084/mp.v3i2.312

Authors

Khairan Khairan Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala Banda Aceh 23111, Indonesia; School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
Farhil Mubaraq Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala Banda Aceh 23111, Indonesia
Nur Balqis Maulydia Graduate School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
Khalijah Awang Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
Rinaldi Idroes Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala Banda Aceh 23111, Indonesia; School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia

DOI:

https://doi.org/10.60084/mp.v3i2.312

Keywords:

Jaboi, Memecylon edule, Syzygium sp., Terpenoids, Thin Layer Chromatography

Abstract

Antimicrobial resistance (AMR) poses an urgent global health concern, prompting the need for alternative therapeutic agents. This study evaluated the antimicrobial potential of ethyl acetate extracts from five medicinal plant species (Memecylon edule, Garcinia dioica, Syzygium sp., Memecylon caeruleum, and Aporosa octandra) collected from the geothermal Jaboi Crater in Aceh, Indonesia. Phytochemical profiling was performed using thin layer chromatography (TLC), and antimicrobial activity was assessed via TLC-bioautography against Escherichia coli, Staphylococcus aureus, and Candida albicans. The results revealed the presence of phenolic and terpenoid compounds, with antibacterial activity observed only against E. coli. No inhibition was detected against S. aureus or C. albicans. The study highlights the selective antimicrobial potential of geothermal plant extracts and underscores the relevance of bioautography as a rapid screening tool. While preliminary, these findings support further investigation into geothermal flora as a source of antibacterial compounds and call for advanced studies to isolate active constituents and explore their mechanisms of action.

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