Bioactive Phytochemicals from Memecylon edule: Targeting Planktonic and Biofilm States of Pseudomonas aeruginosa

Authors

  • Suryawati Suryawati Graduate School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
  • Rinaldi Idroes Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia; School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
  • Triana Hertiani Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
  • Khairan Khairan Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia; School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia

DOI:

https://doi.org/10.60084/mp.v3i1.258

Keywords:

Antimicrobial drug discovery, Geothermal biodiversity, Natural product pharmacology, Antibiofilm innovation, Sustainable antimicrobial sources

Abstract

The rise in antimicrobial resistance has prompted the search for potent antimicrobial agents, with plants from unique environments, such as geothermal areas, offering potential due to their diverse phytochemical profiles. This study evaluated the antiplanktonic and antibiofilm activity of M. edule fractions from the geothermal area, Jaboi, Sabang. Crude extracts of M. edule were sequentially fractionated using hexane, ethyl acetate, and ethanol. The resulting fractions were further analyzed for their phytochemical content and antiplanktonic and antibiofilm activities. The ethyl acetate fraction demonstrated superior antiplanktonic and antibiofilm activities compared to other fractions, inhibiting 50% of Pseudomonas aeruginosa planktonic and biofilm formation at a concentration of 10 mg/mL. The most potent fraction exhibited the phenolic content, 672.84 mg GAE/g extract, surpassing the other fractions. The GC-MS analysis shows the presence of pyrogallol, hexadecanoic acid, cedran-diol, and sitosterol. These findings highlight the potential of the ethyl acetate fraction of M. edule as a source of bioactive compounds with promising antiplanktonic and antibiofilm properties, laying the groundwork for future research into its therapeutic applications against biofilm-associated infections.

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2025-01-07

How to Cite

Suryawati, S., Idroes, R., Hertiani, T., & Khairan, K. (2025). Bioactive Phytochemicals from Memecylon edule: Targeting Planktonic and Biofilm States of Pseudomonas aeruginosa. Malacca Pharmaceutics, 3(1), 10–19. https://doi.org/10.60084/mp.v3i1.258

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Vol. 3 No. 1 (2025): March 2025

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